{
  "resourceType": "CodeSystem",
  "id": "05e3c60a-bf7b-4578-a86d-ba2179a045f7",
  "meta": {
  "versionId": "1",
  "lastUpdated": "2025-07-16T10:53:16.964+00:00"
  },
  "url": "http://genomicsengland.co.uk/gms-clinical-indications",
  "version": "2024-08-22 (NHS-GMS v4)",
  "name": "NHS-GMS Referral Clinical Indications",
  "status": "draft",
  "publisher": "Genomics England",
  "valueSet": "http://genomicsengland.co.uk/gms-clinical-indications",
  "content": "complete",
  "concept": [ {
  "code": "M101",
  "display": "ALK Positive Large B Cell Lymphoma"
  }, {
  "code": "M111",
  "display": "T Cell Non-Hodgkin Lymphoma"
  }, {
  "code": "M112",
  "display": "ALK Negative Anaplastic Large Cell Lymphoma (Including Primary Cutaneous Subtypes)"
  }, {
  "code": "M115",
  "display": "NK Cell/Gamma-Delta T Cell Lymphoma"
  }, {
  "code": "M117",
  "display": "Histiocytosis"
  }, {
  "code": "M119",
  "display": "Paediatric Tumours"
  }, {
  "code": "M120",
  "display": "Atypical Teratoid/Rhabdoid Tumour - Paediatric"
  }, {
  "code": "M124",
  "display": "Clear Cell Kidney Sarcoma - Paediatric"
  }, {
  "code": "M127",
  "display": "Congenital Mesoblastic Nephroma - Paediatric"
  }, {
  "code": "M131",
  "display": "Cystic Nephroma - Paediatric"
  }, {
  "code": "M132",
  "display": "Desmoplastic Infantile Gangliogliomas - Paediatric"
  }, {
  "code": "M133",
  "display": "Desmoplastic Medulloblastoma - Paediatric"
  }, {
  "code": "M138",
  "display": "Glial Tumours - Paediatric"
  }, {
  "code": "M139",
  "display": "Glioblastoma - Paediatric"
  }, {
  "code": "M143",
  "display": "Lung - Paediatric"
  }, {
  "code": "M145",
  "display": "Medulloblastoma - Paediatric"
  }, {
  "code": "M147",
  "display": "Medulloblastoma Group 3/4 - Paediatric"
  }, {
  "code": "M150",
  "display": "Meningioma - Paediatric"
  }, {
  "code": "M152",
  "display": "Neuroblastoma - Paediatric"
  }, {
  "code": "M157",
  "display": "Thyroid Papillary Carcinoma - Paediatric"
  }, {
  "code": "M158",
  "display": "Pilocytic Astrocytoma - Paediatric"
  }, {
  "code": "M160",
  "display": "Pleomorphic Xanthoastrocytoma - Paediatric"
  }, {
  "code": "M161",
  "display": "Pleuropulmonary Blastoma - Paediatric"
  }, {
  "code": "M165",
  "display": "Renal Tumours - Paediatric"
  }, {
  "code": "M166",
  "display": "Retinoblastoma - Paediatric"
  }, {
  "code": "M167",
  "display": "Rhabdoid Tumours - Paediatric"
  }, {
  "code": "M168",
  "display": "Rosette-Forming Glioneuronal Tumour - Paediatric"
  }, {
  "code": "M172",
  "display": "SHH Medulloblastoma - TP53 MUTANT - Paediatric"
  }, {
  "code": "M174",
  "display": "Testicular - Paediatric"
  }, {
  "code": "M178",
  "display": "Wilms Tumours - Paediatric"
  }, {
  "code": "M182",
  "display": "ALK Positive Anaplastic Large Cell Lymphoma"
  }, {
  "code": "M183",
  "display": "Diffuse Midline Glioma - Paediatric"
  }, {
  "code": "M184",
  "display": "Glioma - Paediatric"
  }, {
  "code": "M185",
  "display": "High Grade Glioma - Paediatric"
  }, {
  "code": "M186",
  "display": "Low Grade Glioma - Paediatric"
  }, {
  "code": "M189",
  "display": "Brain Tumour - No Further Morphological Classification - Paediatric"
  }, {
  "code": "M190",
  "display": "Embryonal Tumour Differential - Adult and Paediatric"
  }, {
  "code": "M191",
  "display": "Low Grade Intrinsic Brain Tumour Differential - Adult"
  }, {
  "code": "M192",
  "display": "High Grade Intrinsic Brain Tumour Differential - Adult"
  }, {
  "code": "M193",
  "display": "Unable To Grade Intrinsic Brain Tumour - Adult"
  }, {
  "code": "M194",
  "display": "Medulloblastoma all Subtypes"
  }, {
  "code": "M197",
  "display": "Round Cell Sarcoma of Soft Tissue Differential"
  }, {
  "code": "M198",
  "display": "Vascular Soft Tissue Tumour Differential"
  }, {
  "code": "M199",
  "display": "Spindle Cell Soft Tissue Tumour Differential"
  }, {
  "code": "M2",
  "display": "Ovarian Carcinoma"
  }, {
  "code": "M20",
  "display": "Anaplastic Astrocytoma - Paediatric"
  }, {
  "code": "M200",
  "display": "Myxoid Soft Tissue Tumour Differential"
  }, {
  "code": "M201",
  "display": "Adipocytic Soft Tissue Tumour Differential"
  }, {
  "code": "M202",
  "display": "Epithelioid Soft Tissue Tumour Differential"
  }, {
  "code": "M203",
  "display": "Uterine Sarcomas (Inc Endometrial)"
  }, {
  "code": "M204",
  "display": "Undifferentiated tumour"
  }, {
  "code": "M205",
  "display": "Cartilage Forming Bone Tumour Differential"
  }, {
  "code": "M206",
  "display": "Bone Forming Bone Tumour Differential"
  }, {
  "code": "M207",
  "display": "Osteoclast-Rich Bone Tumour Differential"
  }, {
  "code": "M209",
  "display": "Vascular Tumour of Bone Differential"
  }, {
  "code": "M21",
  "display": "Astrocytoma - Adult"
  }, {
  "code": "M210",
  "display": "Spindle Cell Tumour of Bone Differential"
  }, {
  "code": "M212",
  "display": "Renal Tumour Differential - Paediatric"
  }, {
  "code": "M213",
  "display": "Glial and Glioneuronal Tumour Differential - Paediatric"
  }, {
  "code": "M22",
  "display": "Diffuse Astrocytoma - Paediatric"
  }, {
  "code": "M224",
  "display": "MDS/MPN"
  }, {
  "code": "M226",
  "display": "Cancer of Unknown Primary"
  }, {
  "code": "M23",
  "display": "Diffuse Midline Glioma - Adult"
  }, {
  "code": "M232",
  "display": "Solid Tumour Exhausted all Standards of Care Testing and Treatment- Adult"
  }, {
  "code": "M233",
  "display": "High Grade Ovarian Carcinoma (WGS PILOT)"
  }, {
  "code": "M234",
  "display": "Triple Negative Breast Cancer (WGS PILOT)"
  }, {
  "code": "M235",
  "display": "Proven or Suspected Haematological Tumours Exhausted all Standard of Care Testing and Treatment"
  }, {
  "code": "M24",
  "display": "Embryonal Tumours with Multi-Layered Rosettes - Paediatric"
  }, {
  "code": "M25",
  "display": "Ependymoma - Paediatric"
  }, {
  "code": "M26",
  "display": "Ependymoma - Adult"
  }, {
  "code": "M27",
  "display": "Glioblastoma - Adult"
  }, {
  "code": "M28",
  "display": "Glioma - Adult"
  }, {
  "code": "M29",
  "display": "High Grade Glioma - Adult"
  }, {
  "code": "M30",
  "display": "IDH-Wildtype Glioblastoma - Paediatric"
  }, {
  "code": "M31",
  "display": "Low Grade Glioma - Adult"
  }, {
  "code": "M32",
  "display": "Low Grade Glioma/Glioneuronal Tumours - Adult"
  }, {
  "code": "M33",
  "display": "Meningioma - Adult"
  }, {
  "code": "M35",
  "display": "Oligodendroglioma - Adult"
  }, {
  "code": "M36",
  "display": "Pilocytic Astrocytoma - Adult"
  }, {
  "code": "M37",
  "display": "Pineoblastoma - Paediatric"
  }, {
  "code": "M38",
  "display": "Pituitary Tumours"
  }, {
  "code": "M39",
  "display": "Rare Primitive Neuroectodermal Tumours Groups 2/3 - Paediatric"
  }, {
  "code": "M42",
  "display": "Alveolar Rhabdomyosarcoma"
  }, {
  "code": "M43",
  "display": "Alveolar Soft Part Sarcoma"
  }, {
  "code": "M45",
  "display": "Angiomatoid Fibrous Histiocytoma"
  }, {
  "code": "M46",
  "display": "Chondrosarcoma Conventional Central"
  }, {
  "code": "M47",
  "display": "Chondroblastoma"
  }, {
  "code": "M48",
  "display": "Clear Cell Sarcoma of Soft Tissue"
  }, {
  "code": "M49",
  "display": "CNS Ewing Sarcoma Family Tumour With CIC Alteration"
  }, {
  "code": "M50",
  "display": "Dermatofibrosarcoma Protuberans"
  }, {
  "code": "M52",
  "display": "Desmoplastic Small Round Cell Tumour"
  }, {
  "code": "M55",
  "display": "Ewing Like Sarcoma/PNET"
  }, {
  "code": "M56",
  "display": "Ewing Sarcoma of Bone"
  }, {
  "code": "M57",
  "display": "Ewing-Like Soft-Tissue Sarcoma"
  }, {
  "code": "M58",
  "display": "Extraskeletal Myxoid Chondrosarcoma"
  }, {
  "code": "M60",
  "display": "Giant Cell Tumour of Bone"
  }, {
  "code": "M61",
  "display": "High-Grade Neuroepithelial Tumour-Bcor Group"
  }, {
  "code": "M62",
  "display": "Infantile Fibrosarcoma"
  }, {
  "code": "M63",
  "display": "Inflammatory Myofibroblastic Tumour"
  }, {
  "code": "M64",
  "display": "Low Grade Fibromyxoid Sarcoma"
  }, {
  "code": "M65",
  "display": "Mesenchymal Chondrosarcoma"
  }, {
  "code": "M67",
  "display": "Myxoid/Round Cell Liposarcoma"
  }, {
  "code": "M68",
  "display": "Myxoinflammatory Fibroblastic Sarcoma"
  }, {
  "code": "M70",
  "display": "Osteosarcoma"
  }, {
  "code": "M71",
  "display": "Phosphaturic Mesenchymal Tumour"
  }, {
  "code": "M72",
  "display": "Primitive Mesenchymal Myxoid Tumour of Infancy"
  }, {
  "code": "M73",
  "display": "Pseudomyogenic Haemangioendothelioma"
  }, {
  "code": "M74",
  "display": "Radiation Induced Angiosarcoma"
  }, {
  "code": "M75",
  "display": "Round Cell Sarcoma Nos"
  }, {
  "code": "M77",
  "display": "Synovial Sarcoma"
  }, {
  "code": "M78",
  "display": "Undifferentiated Round Cell Sarcoma of Infancy"
  }, {
  "code": "M79",
  "display": "Well Differentiated/Dedifferentiated Liposarcoma"
  }, {
  "code": "M80",
  "display": "Acute Myeloid Leukaemia"
  }, {
  "code": "M82",
  "display": "Myelodysplasia"
  }, {
  "code": "M83",
  "display": "Aplastic Anaemia"
  }, {
  "code": "M84",
  "display": "Chronic Myeloid Leukaemia"
  }, {
  "code": "M85",
  "display": "Myeloproliferative Neoplasm"
  }, {
  "code": "M88",
  "display": "Juvenile Myelomonocytic Leukaemia"
  }, {
  "code": "M89",
  "display": "Acute Leukaemia Other"
  }, {
  "code": "M90",
  "display": "Blastic Plasmacytoid Dendritic Cell Neoplasm"
  }, {
  "code": "M91",
  "display": "Acute Lymphoblastic Leukaemia"
  }, {
  "code": "M93",
  "display": "Lymphoma"
  }, {
  "code": "M95",
  "display": "B Cell Non-Hodgkin Lymphoma"
  }, {
  "code": "M96",
  "display": "Burkitt Lymphoma"
  }, {
  "code": "M99",
  "display": "High Grade Lymphoma"
  }, {
  "code": "R100",
  " ...